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ea0090oc1.2 | Oral Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2023

Semaglutide alters tongue transcriptome along with the improvement of taste perception and increased brain activation in response to sweet tasting solution in obese women with PCOS

Jensterle Mojca , Vovk Andrej , Kovac Jernej , Battelino Saba , Ferjan Simona , Hrast Barbara , Battelino Tadej , Janez Andrej

Background: Obese individuals may perceive the taste of caloric dense food as less intense, resulting in decreased activation of the reward system. Preclinical research provides some insights into the role of GLP-1 in the gustatory coding. The impact of GLP-1 receptor agonists on the tongue and taste perception remains largely unaddressed in clinical settings.Aim: to investigate the impact of semaglutide on the tongue transcriptome, taste perception and ...

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Semaglutide alters tongue transcriptome along with the improvement of taste perception and increased brain activation in response to sweet tasting solution in obese women with PCOS

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